6″ September “2022
Horumarinta tallaalka mustaqbalka waxaa laga yaabaa inay dhiirigeliso natiijooyinka Unugyada ka-hortagga daweynta ee waxtarka lahaa horraantii masiibada ayaa lumiyay waxtarkooda maadaama SARS-CoV-2 ay is beddeshay oo is beddeshay, iyo kala duwanaanshihii ugu dambeeyay, gaar ahaan Omicron, waxay barteen sida loo hareer maro unugyada difaaca jirka ee nidaamyadayadu soo saaraan si looga jawaabo tallaallada.
Waxaa laga yaabaa inaan si wanaagsan uga ilaalino kala duwanaanshiyaha suurtagalka ah iyadoo ay ugu wacan tahay unug cusub oo dhexdhexaadin ah oo laga sameeyay Isbitaalka Carruurta Boston. Tijaabooyin, waxay ka takhalustay dhammaan noocyada SARS-CoV-2 ee la yaqaan ee walaaca, oo ay ku jiraan dhammaan noocyada Omicron.
“Waxaan rajeyneynaa in antibody-ka bini’aadmigu uu caddeeyo inuu waxtar u leeyahay ka takhalusidda SARS-CoV-2 ee bukaannada sida ay caddeeyeen inay ilaa hadda ku jiraan qiimeynta saxda ah,” ayuu yiri Frederick Alt, Ph.D., oo ka tirsan Barnaamijka Cellular iyo Daawada Molecular ee Isbitaalka Carruurta ee Boston, oo ka qayb qaatay cilmi-baarista.
Daraasad lagu daabacay Sayniska Immunology, Alt iyo Sai Luo, Ph.D., waxay adeegsadeen nooc la beddelay oo ah moodal jiir bani’aadam ah oo shaybaarkiisu hore u isticmaali jiray si uu u raadiyo unugyada difaaca jirka ee HIV, fayras kale oo inta badan isbeddela.
Maadaama ay jiirarku si wax ku ool ah u dhisteen nidaamyada difaaca aadanaha, qaabku wuxuu si dhow u shabbahay sida habka tijaabinta-iyo-qallada ee habka difaacayagu u isticmaalo si loo abuuro unugyada difaaca ee sii kordheysa ee waxtarka leh.
Cilmi-baadhayaashu waxay markii hore soo bandhigeen laba qaybood oo hiddo-wadaha bini’aadamka ah oo ku jira jiirarka, taas oo keentay in unugyadooda B ay abuuraan muuqaal ballaadhan oo ka hortagga unugyada aadanaha muddo gaaban gudaheed. Ka dib waxay daaha ka qaadeen jiirarka asalka Wuhan-Hu-1 ee borotiink壯陽藥 a fayraska ee SARS-CoV-2, kaas oo ah borotiinka ugu weyn ee ay bartilmaameedsadaan unugyada difaaca jirka iyo tallaalada hadda jira. Jiirarka wax laga beddelay waxay soo saareen sagaal abtirsiinyo, ama “qoysaska”, unugyada difaaca aadanaha ee ku xidhan sareynta jawaabta.
Si wada jir ah oo ay weheliyaan kooxda Duke University oo uu hogaaminayo Dr. Barton Haynes, Alt iyo Luo ayaa markaa qiimeeyay waxtarka unugyada difaacayaashan. Unugyada difaaca ee saddex ka mid ah sagaalka abtirsiimada ayaa wax ku ool u ahaa baabi’inta fayraska asalka ah ee Wuhan-Hu-1. Difaacayaasha SP1-77 iyo xubnaha kale ee nasabkeeda, gaar ahaan, waxay muujiyeen waxqabad aad u ballaaran, oo ka takhalusay Alpha, Beta, Gamma, Delta, iyo dhammaan noocyada Omicron ee ka horreeyay iyo kuwa hadda jira.
Si wada jir ah oo ay weheliyaan koox Jaamacadda Duke ah oo uu hoggaaminayo Dr. Barton Haynes, Alt iyo Luo ayaa markaa qiimeeyay waxtarka unugyada difaacayaashan. Unugyada difaaca ee saddex ka mid ah sagaalka abtirsiimada ayaa wax ku ool u ahaa baabi’inta fayraska asalka ah ee Wuhan-Hu-1. Difaacayaasha SP1-77 iyo xubnaha kale ee nasabkeeda, gaar ahaan, waxay muujiyeen waxqabad aad u ballaaran, oo ka takhalusay Alpha, Beta, Gamma, Delta, iyo dhammaan noocyada Omicron ee ka horreeyay iyo kuwa hadda jira.
Habka cusub ee ka hortagga fayraska
Maxaa keenay in antibody-ka SP1-77 uu si ballaaran u dhexdhexaadiyo? Daraasado qaab dhismeed ah oo ay sameeyeen koox iskaashanaya oo uu hogaaminayo Bing Chen, Ph.D. iyo Jun Zhang, Ph.D. Isbitaalka Carruurta Boston iyo kooxda Haynes ee Duke, waxay muujiyeen in SP1-77 ay u shaqeyso si ka duwan unugyada difaaca jirka (ha ahaato unugyada daweynta ama kuwa aan sameyno si looga jawaabo tallaallada hadda jira).
Qaar badan oo ka mid ah unugyada difaaca jirka waxay u shaqeeyaan iyagoo ku dhejinaya xayndaabka-qabta-qabtayaasha (RBD) ee qulqulka gobollada qaarkood, ka hortagga SARS-CoV-2 inay ku xidhaan qabayaasha ACE2 unugyadeena, taas oo ah tallaabada ugu horreysa ee caabuqa. Difaaca jirka ee SP1-77 wuxuu sidoo kale ku xiraa RBD, laakiin si gebi ahaanba ka duwan oo aan ka hortageynin fayraska inuu ku xiro soo-dhoweyaasha ACE2.
Adigoo isticmaalaya madal sawir-unug novel ah oo lagu sifeeyay daabacaad hore, wada-shaqeeyayaasha Alex Kreutzberger, Ph.D. iyo Tomas Kirchhausen, Ph.D., oo ka tirsan Isbitaalka Carruurta ee Boston ayaa muujiyay in SP1-77 ay ka hortagto fayraska inuu ku dabo xuubkiisa dibadda xuubka unugyada bartilmaameedka ah. Tani waxay ka hortagtaa tallaabada ugu dambeysa ee lagama maarmaanka ah ee ka saarta albaabka u furan caabuqa.
Tilmaamahani waxa laga yaabaa inay ku wargeliyaan naqshadaynta tallaallada cusub ee SARS-CoV-2. “SP1-77 waxay ku xidhaa borotiinka sare ee goob aan ilaa hadda lagu beddelin nooc kasta oo SARS-CoV-2 ah, taasoo si ballaadhan uga takhalusaysa noocyada hadda jira hab cusub,” ayuu yidhi Kirchhausen.
Daraasada waxaa maalgeliyay Howard Hughes Medical Institute, Bill & Melinda Gates Foundation, NIH NIAID Consortia for HIV/AIDS Consortia for HIV/AIDS Consortium, Massachusetts Consortium on Pathogen Readiness, Emergent Ventures, the Food and Drug Administration, NIH Maximizing Investigators’ Abaalmarinta Cilmi-baarista, NIH Grant AI163019, Jaamacadda Farsamada ee Danishka iyo SANA, IONIS, iyo deeqda tababbarka ee Barnaamijka Harvard Virology ee NIH.
Alt iyo Ming Tian, Ph.D., ee Boston Children’s waa qorayaasha arjiga patent-ka ee qeexaya qaabka jiirka. Luo, Haynes, iyo Alt waa qorayaasha codsiyada patent-ka ee qeexaya unugyada difaaca jirka.
