Friday ” 11″ February “2022” CNN
Calaamadaha hore ee rajada la helay ayaa sheegaya ka dib, daraasadd lagu sameeyay Kaniiniga Laab jeexa ee caanka ah in ay muujisay natiijooyin isku dhafan oo ka dhan ah Covid-19
Hal mar oo ah bilowga masiibada, waxaa jirtay rajo ah in dawada laabjeexa ee caanka ah oo raqiis ah laga yaabo inay ballan qaaddo daawaynta Covid-19, laakiin daraasad dhowaan la daabacay ayaa muujisay natiijooyin isku dhafan.
Tijaabada caafimaadka, dadka qaba Covid-19 dhexdhexaad ama dhexdhexaad ah oo qaatay qiyaaso aad u sarreeya oo famotidine ah, oo ah walaxda firfircoon ee Pepcid, ayaa waxoogaa horumar ah ku yeeshay calamahooda si ka dhakhso badan kuwa qaatay placebo, kaniini aan waxba samayn.
Laakiin tijaabadan oo la aaminsan yahay inay tahay tii ugu horeysay ee nooceeda ah, ayaa ahayd mid yar, saameyntuna aad ayay uga fogaatay. 55 ka mid ah ka qaybgalayaasha daraasadda, kuwa loo qoondeeyay inay qaataan famotidine ayaa lagu qiyaasay 50% hoos u dhaca calaamadaha 8.2 maalmood, iyo kuwa loo qoondeeyey placebo waxay arkeen hoos u dhaca 11.4 maalmood.
ilaa dhexdhexaad Covid-19 kuwaas oo qaatay qiyaaso aad u sarreeya oo famotidine ah, oo ah walaxda firfircoon ee Pepcid, ayaa waxoogaa horumar ah ku yeeshay astaamahooda si ka dhakhso badan kuwa qaatay placebo, kaniini aan waxba samayn.
Laakiin tijaabadan oo la aaminsan yahay inay tahay tii ugu horeysay ee nooceeda ah, ayaa ahayd mid yar, saameyntuna aad ayay uga fogaatay. 55 ka mid ah ka qaybgalayaasha daraasadda, kuwa loo qoondeeyay inay qaataan famotidine ayaa lagu qiyaasay 50% hoos u dhaca calaamadaha 8.2 maalmood, iyo kuwa loo qoondeeyey placebo waxay arkeen hoos u dhaca 11.4 maalmood.
“Gabi ahaanba aad ayaan u murugaysanahay,” ayuu yidhi Dr. Carlos del Rio, madaxwaynaha la doortay ee Ururka Cudurada Faafa ee Ameerika.
“Xaqiiqdii ma raynayso mootada,” ayuu yidhi Dr. William Schaffner, khabiir cudurada faafa oo u adeega lataliyaha tallaalka ee Xarumaha Xakamaynta iyo Kahortagga Cudurrada ee Maraykanka. Isaga iyo del Rio midna kama shaqayn daraasadda.
Tijaabada caafimaad, ka qaybgalayaashu waxay qaateen 80 milligaraam oo famotidine saddex jeer maalintii muddo 14 maalmood ah. Qiyaastaasi waxay lix jeer ka sarraysaa qiyaasta ugu sarreysa ee lagu taliyey ee Pepcid.
Tifaftiraha guud ee Gut, joornaalka daabacay wargeyska Khamiista, ayaa ugu yeeray hagaajinta bukaannada famotidine “mid dhexdhexaad ah laakiin muhiim ah.”
Dr. Emad El-Omar wuxuu tilmaamay in laba toddobaad ka dib, laba jibaar in ka badan dadka la siiyay placebo ay ku sii jiraan calaamadaha calaamadaha kuwa qaatay famotidine.
“Tani waa cajiib!” El-Omar, oo ah borofisar cilmiga caafimaadka ka dhiga Jaamacadda New South Wales Sydney ee Australia, ayaa email u soo diray CNN.
Xiisaha Famotidine wuxuu ka bilaabmay Shiinaha
Xiisaha famotidine ee lagu daweynayo Covid-19 waxay asal ahaan ka soo jeedaan Shiinaha, sida uu qabo Dr. Kevin Tracey, oo wax ka qoray daraasadda Gut.
Bishii Abriil 2020, Tracey waxay u sheegtay CNN in dhakhaatiirta halkaas joogta ay arkeen in dadka qaarkiis ee dakhligoodu hooseeyo ee qabtay coronavirus ay ka badbaadeen in ka badan kuwa dhiggooda ah ee hodanka ah ee sidoo kale qaba wadno-xanuun. Markii ay si aad ah u eegeen, waxay ogaadeen in qaar badan oo ka mid ah bukaannada dakhligoodu hooseeyo ay qaadanayaan famotidine, halka bukaannada dhaqaalaha leh ay u badan yihiin inay qaataan daawo qaali ah oo lagu daweeyo laabjeexa.
“Beeralayda saboolka ah waxay runtii u muuqdeen inay si wanaagsan wax ugu qabanayaan famotidine,” Tracey, oo madax ka ah Machadka Feinstein ee Cilmi-baarista Caafimaadka ee Northwell Health ee New York, ayaa yiri waqtigaas. “Waxaa jira qisooyin badan oo hareeraha ka socda oo xoogaa rajo ah na gelinaya.
Rajadu si gaar ah ayey u xoog badneyd maxaa yeelay Covid-19 wuxuu ku sii qulqulayay New York waqtigaas, famotidine-na waa mid raqiis ah wuxuuna leeyahay rikoor dheer oo dawo ammaan ah.
Dhawr bilood ka dib, Tracey iyo kooxdiisa oo jooga Northwell iyo Cold Spring Harbor Laboratory ee New York ayaa soo sheegay in 10 qof oo ka soo kabanaya Covid-19 gurigooda oo ku yaal Maraykanka iyo Iswidhan ay ogaadeen “horumar degdeg ah” xaaladdooda maalin ama laba maalmood gudahooda markay bilaabeen. famotidine.
Kooxdu waxay markaa isku dayeen inay tijaabiyaan dawada bukaannada isbitaallada la dhigo, laakiin waxay ku dhacday dhibaato maadaama xulashooyin kale oo daaweyn ah ay heleen tirada sii yaraanaysa ee bukaannada Covid-19 ee New York. Daraasadaas ayaa aakhirkii burburtay.
Famotidine ayaa mar kale samaysay war markii madaxwaynihii hore ee Donald Trump lagu daweeyay daawada markii cisbitaalka la dhigay Covid-19 bishii Diseembar 2020.
Pfizer’s Covid-19 kiniiniga kahortaga fayraska waxaa lagu amaanay inuu yahay bedel ciyaarta, laakiin saadka ayaa aad u yar
Laakiin dhawr bilood ka dib, daraasad ay sameeyeen cilmi-baarayaal ka socday laba shirkadood oo dawooyin ah ayaa lagu ogaaday in famotidine aysan caawinin dadka isbitaallada jiifa.
Ururka Cudurada Faafa ee Ameerika waxa ay ku talinaysaa ka hortagga isticmaalka famotidine si loogu daweeyo bukaannada Covid-19 ee cisbitaalka oo aan lahayn wax talo ah oo ku saabsan ama looga soo horjeedo isticmaalka dadka aan cisbitaalka ku jirin.
Bishii Abriil 2020, Machadka Qaranka ee Caafimaadka ayaa ku dhawaaqay iskaashi dadweyne iyo kuwo gaar loo leeyahay si loo dardargeliyo daraasadda dawooyinka suurtagalka ah ee lagu daweyn karo Covid-19, oo ay ku jiraan ilaa laba darsin “dib loo soo celiyay” oo mar horeba loo isticmaalay in lagu daweeyo xaalado kale. Famotidine kuma jiro liiska.
Tallaabooyinka xiga ma cadda
Hadda, daraasadda famotidine ee lagu daweynayo Covid-19 waxay maraysaa meel isgoys ah.
Kooxda Northwell iyo Cold Spring Harbor waxay ka fiirsanayaan sida ugu wanaagsan ee loo qaabayn karo tijaabo caafimaad oo weyn taasoo famotidine gelinaysa tijaabada.
“Miyaynu ka qaadan karnaa dawo badbaado leh shelf, mid la soo saari karo [oo asal ahaan] la siiyo wadamada aan haysan wax lagu daweeyo Covid?” Tracey ayaa waydiisay. “Waa su’aal muhiim u ah caafimaadka caalamka.”
Qof kastaa ma ogola.
Schaffner iyo del Rio, khubarada cudurada faafa, waxay yiraahdeen ma jirto sabab lacag loogu isticmaalo tijaabo caafimaad oo weyn oo famotidine ah, gaar ahaan sababtoo ah gudaha Mareykanka, waxaa jira dawooyin ka hortaga fayraska iyo unug ka hortag ah oo monoclonal ah oo loo oggolaaday in lagu daweeyo Covid- marxaladda hore.
Waxay intaa ku dareen in haddii qof qaba Covid-19 uu rabo inuu isku dayo famotidine, ay u badan tahay inaysan jirin wax dhibaato ah.
Schaffner, oo ah khabiir ku takhasusay cudurrada faafa oo ka tirsan Xarunta Caafimaadka ee Jaamacadda Vanderbilt ayaa yidhi: “Dhinaca hoose ee arrintani waa waxba, markaa waxaan odhan lahaa hubso, isku day, laakiin wax badan ha filanina.”
Khabiir kale oo cudurrada faafa ayaa u arka faamotidine ballan-qaadyo badan oo suurtagal ah
Dr. Pau犀利士 l Offit wuxuu tilmaamay natiijooyinka daraasaddan cusub ee baaray calaamadaha caabuqa ee dhiigga 35 ee kaqeybgalayaasha. Natiijooyinkaasi waxay muujiyeen in dadka ku jira famotidine ay bararkooda xaliyeen si ka dhaqso badan kuwa ku jira placebo.
NIH waxa ay ku talinaysaa in la isticmaalo tocilizumab, daawada arthritis-ka ka-hortagga caabuqa, si loogu daweeyo bukaannada Covid ee isbitaalada jiifa.
“Famotidine waa nooc ka mid ah tocilizumab nin faqiir ah,” ayuu yiri Offit, xubin ka tirsan Guddiga La-talinta ee Maamulka Cuntada iyo Dawooyinka ee Maamulka Cuntada iyo Dawooyinka ee Mareykanka. Waxa uu intaa ku daray in famotidine ay yeelan doonto saameyn aad uga yar marka loo eego tocilizumab, laakiin sidoo kale waxay yeelan doontaa saameyn yar.
Offit waxay dhiirigelisay cilmi baaris dheeri ah oo ku saabsan famotidine si loogu daweeyo Covid-19.
“Mar walba waxaan u socdaa inaan wax badan barto. Taasi waa magangalkii ugu dambeeyay ee ceebta tacliinta: daraasado badan,” ayuu yiri Offit.